Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)
Identifieur interne : 002947 ( Main/Corpus ); précédent : 002946; suivant : 002948Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)
Auteurs : F. Loew ; K. Loew ; R. KivelitzSource :
- Acta Neurochirurgica [ 0001-6268 ] ; 1982-03-01.
Abstract
Summary: An analysis is given of a series of 25 patients suffering from lumboischialgic pain of different causes, which have been treated by discolysis. Literature reports are taken into consideration. As a result of analysis, the following statements seem justified: In no kind of lumbar disc prolapse are the results of discolysis superior to those of modern operative treatment. Discolysis results are indisputably worse in cases with the usual operative indication, which consists of neurological deficit and large disc prolapse. Favourable results by discolysis can be obtained in cases with disc protrusion or small prolapse, but these cases can mostly be cured also by consequent conservative treatment. Contraindications are marked neurological deficit, demonstration of a large disc prolapse by contrast methods, Verbiest's stenosis of the lumbar spinal canal, low back pain and ischialgia without positive proof of a disc protrusion, cases with low back pain as the main or only feature, spondylolisthesis. Disc prolapse recurrences after discolysis often occur about one month afterwards. Structural instability at this stage is likely. Therefore, as with post-operative treatment, it is advisable to avoid major physical stress for the first weeks after discolysis. Major complications after discolysis are possible, and have occurred. Because discolysis offers no real advantages but some shortcomings compared to conservative treatment for disc protrusions, and to operative treatment in real disc prolapses, its justification seems more than questionable.
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DOI: 10.1007/BF01740073
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)</title><author><name sortKey="Loew, F" sort="Loew, F" uniqKey="Loew F" first="F." last="Loew">F. Loew</name><affiliation><mods:affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Loew, K" sort="Loew, K" uniqKey="Loew K" first="K." last="Loew">K. Loew</name><affiliation><mods:affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kivelitz, R" sort="Kivelitz, R" uniqKey="Kivelitz R" first="R." last="Kivelitz">R. Kivelitz</name><affiliation><mods:affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1</idno><date when="1982" year="1982">1982</date><idno type="doi">10.1007/BF01740073</idno><idno type="url">https://api.istex.fr/document/6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002947</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)</title><author><name sortKey="Loew, F" sort="Loew, F" uniqKey="Loew F" first="F." last="Loew">F. Loew</name><affiliation><mods:affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Loew, K" sort="Loew, K" uniqKey="Loew K" first="K." last="Loew">K. Loew</name><affiliation><mods:affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kivelitz, R" sort="Kivelitz, R" uniqKey="Kivelitz R" first="R." last="Kivelitz">R. Kivelitz</name><affiliation><mods:affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurochirurgica</title><title level="j" type="sub">The European Journal of Neurosurgery</title><title level="j" type="abbrev">Acta neurochir</title><idno type="ISSN">0001-6268</idno><idno type="eISSN">0942-0940</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1982-03-01">1982-03-01</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">1-3</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="88">88</biblScope></imprint><idno type="ISSN">0001-6268</idno></series><idno type="istex">6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1</idno><idno type="DOI">10.1007/BF01740073</idno><idno type="ArticleID">Art8</idno><idno type="ArticleID">BF01740073</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6268</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: An analysis is given of a series of 25 patients suffering from lumboischialgic pain of different causes, which have been treated by discolysis. Literature reports are taken into consideration. As a result of analysis, the following statements seem justified: In no kind of lumbar disc prolapse are the results of discolysis superior to those of modern operative treatment. Discolysis results are indisputably worse in cases with the usual operative indication, which consists of neurological deficit and large disc prolapse. Favourable results by discolysis can be obtained in cases with disc protrusion or small prolapse, but these cases can mostly be cured also by consequent conservative treatment. Contraindications are marked neurological deficit, demonstration of a large disc prolapse by contrast methods, Verbiest's stenosis of the lumbar spinal canal, low back pain and ischialgia without positive proof of a disc protrusion, cases with low back pain as the main or only feature, spondylolisthesis. Disc prolapse recurrences after discolysis often occur about one month afterwards. Structural instability at this stage is likely. Therefore, as with post-operative treatment, it is advisable to avoid major physical stress for the first weeks after discolysis. Major complications after discolysis are possible, and have occurred. Because discolysis offers no real advantages but some shortcomings compared to conservative treatment for disc protrusions, and to operative treatment in real disc prolapses, its justification seems more than questionable.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>F. Loew</name><affiliations><json:string>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</json:string></affiliations></json:item><json:item><name>K. Loew</name><affiliations><json:string>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</json:string></affiliations></json:item><json:item><name>R. Kivelitz</name><affiliations><json:string>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</json:string></affiliations></json:item></author><articleId><json:string>Art8</json:string><json:string>BF01740073</json:string></articleId><language><json:string>eng</json:string></language><abstract>Summary: An analysis is given of a series of 25 patients suffering from lumboischialgic pain of different causes, which have been treated by discolysis. Literature reports are taken into consideration. As a result of analysis, the following statements seem justified: In no kind of lumbar disc prolapse are the results of discolysis superior to those of modern operative treatment. Discolysis results are indisputably worse in cases with the usual operative indication, which consists of neurological deficit and large disc prolapse. Favourable results by discolysis can be obtained in cases with disc protrusion or small prolapse, but these cases can mostly be cured also by consequent conservative treatment. Contraindications are marked neurological deficit, demonstration of a large disc prolapse by contrast methods, Verbiest's stenosis of the lumbar spinal canal, low back pain and ischialgia without positive proof of a disc protrusion, cases with low back pain as the main or only feature, spondylolisthesis. Disc prolapse recurrences after discolysis often occur about one month afterwards. Structural instability at this stage is likely. Therefore, as with post-operative treatment, it is advisable to avoid major physical stress for the first weeks after discolysis. Major complications after discolysis are possible, and have occurred. Because discolysis offers no real advantages but some shortcomings compared to conservative treatment for disc protrusions, and to operative treatment in real disc prolapses, its justification seems more than questionable.</abstract><qualityIndicators><score>7.736</score><pdfVersion>1.3</pdfVersion><pdfPageSize>414 x 641 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1570</abstractCharCount><pdfWordCount>6268</pdfWordCount><pdfCharCount>38187</pdfCharCount><pdfPageCount>16</pdfPageCount><abstractWordCount>228</abstractWordCount></qualityIndicators><title>Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)</title><genre><json:string>research-article</json:string></genre><host><volume>61</volume><pages><last>88</last><first>73</first></pages><issn><json:string>0001-6268</json:string></issn><issue>1-3</issue><subject><json:item><value>Interventional Radiology</value></json:item><json:item><value>Neuroradiology</value></json:item><json:item><value>Neurology</value></json:item><json:item><value>Neurosurgery</value></json:item><json:item><value>Surgical Orthopedics</value></json:item><json:item><value>Minimally Invasive Surgery</value></json:item></subject><journalId><json:string>701</json:string></journalId><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>0942-0940</json:string></eissn><title>Acta Neurochirurgica</title><publicationDate>1982</publicationDate><copyrightDate>1982</copyrightDate></host><publicationDate>1982</publicationDate><copyrightDate>1982</copyrightDate><doi><json:string>10.1007/BF01740073</json:string></doi><id>6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)</title><title level="a" type="sub" xml:lang="en">Analysis of literature and personal experiences</title><respStmt xml:id="ISTEX-API" resp="Références bibliographiques récupérées via GROBID" name="ISTEX-API (INIST-CNRS)"></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><availability><p>SPRINGER</p></availability><date>1982</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)</title><title level="a" type="sub" xml:lang="en">Analysis of literature and personal experiences</title><author><persName><forename type="first">F.</forename><surname>Loew</surname></persName><affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</affiliation></author><author><persName><forename type="first">K.</forename><surname>Loew</surname></persName><affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</affiliation></author><author><persName><forename type="first">R.</forename><surname>Kivelitz</surname></persName><affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</affiliation></author></analytic><monogr><title level="j">Acta Neurochirurgica</title><title level="j" type="sub">The European Journal of Neurosurgery</title><title level="j" type="abbrev">Acta neurochir</title><idno type="JournalID">701</idno><idno type="pISSN">0001-6268</idno><idno type="eISSN">0942-0940</idno><idno type="IssueArticleCount">25</idno><idno type="VolumeIssueCount">4</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1982-03-01"></date><biblScope unit="volume">61</biblScope><biblScope unit="issue">1-3</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="88">88</biblScope></imprint></monogr><idno type="istex">6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1</idno><idno type="DOI">10.1007/BF01740073</idno><idno type="ArticleID">Art8</idno><idno type="ArticleID">BF01740073</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1982</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: An analysis is given of a series of 25 patients suffering from lumboischialgic pain of different causes, which have been treated by discolysis. Literature reports are taken into consideration. As a result of analysis, the following statements seem justified: In no kind of lumbar disc prolapse are the results of discolysis superior to those of modern operative treatment. Discolysis results are indisputably worse in cases with the usual operative indication, which consists of neurological deficit and large disc prolapse. Favourable results by discolysis can be obtained in cases with disc protrusion or small prolapse, but these cases can mostly be cured also by consequent conservative treatment. Contraindications are marked neurological deficit, demonstration of a large disc prolapse by contrast methods, Verbiest's stenosis of the lumbar spinal canal, low back pain and ischialgia without positive proof of a disc protrusion, cases with low back pain as the main or only feature, spondylolisthesis. Disc prolapse recurrences after discolysis often occur about one month afterwards. Structural instability at this stage is likely. Therefore, as with post-operative treatment, it is advisable to avoid major physical stress for the first weeks after discolysis. Major complications after discolysis are possible, and have occurred. Because discolysis offers no real advantages but some shortcomings compared to conservative treatment for disc protrusions, and to operative treatment in real disc prolapses, its justification seems more than questionable.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Interventional Radiology</term></item><item><term>Neuroradiology</term></item><item><term>Neurology</term></item><item><term>Neurosurgery</term></item><item><term>Surgical Orthopedics</term></item><item><term>Minimally Invasive Surgery</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1982-03-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-2">References 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TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>3</IssueIDEnd><IssueArticleCount>25</IssueArticleCount><IssueHistory><CoverDate><DateString>1982</DateString><Year>1982</Year><Month>3</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1982</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art8"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF01740073</ArticleID><ArticleDOI>10.1007/BF01740073</ArticleDOI><ArticleSequenceNumber>8</ArticleSequenceNumber><ArticleTitle Language="En">Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)</ArticleTitle><ArticleSubTitle Language="En">Analysis of literature and personal experiences</ArticleSubTitle><ArticleFirstPage>73</ArticleFirstPage><ArticleLastPage>88</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>5</Month><Day>5</Day></RegistrationDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1982</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>701</JournalID><VolumeIDStart>61</VolumeIDStart><VolumeIDEnd>61</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>3</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" PresentAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>F.</GivenName><FamilyName>Loew</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Loew</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>R.</GivenName><FamilyName>Kivelitz</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Neurosurgical Clinic of the Saarland University</OrgName><OrgAddress><City>Homburg</City><State>Saar</State><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>An analysis is given of a series of 25 patients suffering from lumboischialgic pain of different causes, which have been treated by discolysis. Literature reports are taken into consideration.</Para><Para>As a result of analysis, the following statements seem justified:</Para><Para>In no kind of lumbar disc prolapse are the results of discolysis superior to those of modern operative treatment. Discolysis results are indisputably worse in cases with the usual operative indication, which consists of neurological deficit and large disc prolapse. Favourable results by discolysis can be obtained in cases with disc protrusion or small prolapse, but these cases can mostly be cured also by consequent conservative treatment.</Para><Para>Contraindications are marked neurological deficit, demonstration of a large disc prolapse by contrast methods, Verbiest's stenosis of the lumbar spinal canal, low back pain and ischialgia without positive proof of a disc protrusion, cases with low back pain as the main or only feature, spondylolisthesis.</Para><Para>Disc prolapse recurrences after discolysis often occur about one month afterwards. Structural instability at this stage is likely. Therefore, as with post-operative treatment, it is advisable to avoid major physical stress for the first weeks after discolysis.</Para><Para>Major complications after discolysis are possible, and have occurred. Because discolysis offers no real advantages but some shortcomings compared to conservative treatment for disc protrusions, and to operative treatment in real disc prolapses, its justification seems more than questionable.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>Discolysis</Keyword><Keyword>disc prolapse</Keyword><Keyword>disc protrusion</Keyword><Keyword>disc operation</Keyword><Keyword>lumbar</Keyword><Keyword>stenosis</Keyword><Keyword>spondylolisthesis</Keyword><Keyword>spondylodiscitis</Keyword><Keyword>lumboischialgia</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)</title><subTitle>Analysis of literature and personal experiences</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Treatment of lumbo-ischialgias of different origins by intradiscal injection of chymopapain (discolysis)</title><subTitle>Analysis of literature and personal experiences</subTitle></titleInfo><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Loew</namePart><affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Loew</namePart><affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Kivelitz</namePart><affiliation>Neurosurgical Clinic of the Saarland University, Homburg, Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateIssued encoding="w3cdtf">1982-03-01</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: An analysis is given of a series of 25 patients suffering from lumboischialgic pain of different causes, which have been treated by discolysis. Literature reports are taken into consideration. As a result of analysis, the following statements seem justified: In no kind of lumbar disc prolapse are the results of discolysis superior to those of modern operative treatment. Discolysis results are indisputably worse in cases with the usual operative indication, which consists of neurological deficit and large disc prolapse. Favourable results by discolysis can be obtained in cases with disc protrusion or small prolapse, but these cases can mostly be cured also by consequent conservative treatment. Contraindications are marked neurological deficit, demonstration of a large disc prolapse by contrast methods, Verbiest's stenosis of the lumbar spinal canal, low back pain and ischialgia without positive proof of a disc protrusion, cases with low back pain as the main or only feature, spondylolisthesis. Disc prolapse recurrences after discolysis often occur about one month afterwards. Structural instability at this stage is likely. Therefore, as with post-operative treatment, it is advisable to avoid major physical stress for the first weeks after discolysis. Major complications after discolysis are possible, and have occurred. Because discolysis offers no real advantages but some shortcomings compared to conservative treatment for disc protrusions, and to operative treatment in real disc prolapses, its justification seems more than questionable.</abstract><relatedItem type="host"><titleInfo><title>Acta Neurochirurgica</title><subTitle>The European Journal of Neurosurgery</subTitle></titleInfo><titleInfo type="abbreviated"><title>Acta neurochir</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1982-03-01</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Interventional Radiology</topic><topic>Neuroradiology</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Surgical Orthopedics</topic><topic>Minimally Invasive Surgery</topic></subject><identifier type="ISSN">0001-6268</identifier><identifier type="eISSN">0942-0940</identifier><identifier type="JournalID">701</identifier><identifier type="IssueArticleCount">25</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1982</date><detail type="volume"><number>61</number><caption>vol.</caption></detail><detail type="issue"><number>1-3</number><caption>no.</caption></detail><extent unit="pages"><start>73</start><end>88</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1982</recordOrigin></recordInfo></relatedItem><identifier type="istex">6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1</identifier><identifier type="DOI">10.1007/BF01740073</identifier><identifier type="ArticleID">Art8</identifier><identifier type="ArticleID">BF01740073</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1982</recordOrigin></recordInfo></mods></metadata><enrichments><istex:refBibTEI uri="https://api.istex.fr/document/6CF61DB364440BEBE793F0F1D34367CF3F3DDEF1/enrichments/refBib"><teiHeader></teiHeader><text><front></front><body></body><back><listBibl><biblStruct xml:id="b0"><analytic><title level="a" type="main">Tissue response to Chymopapain in different concentrations: animal investigations on microvascular effects</title><author><persName><forename type="first">P.-I</forename><surname>Branemark</surname></persName></author><author><persName><forename type="first">R</forename><surname>Ekholm</surname></persName></author><author><persName><forename type="first">J</forename><surname>Lundskog</surname></persName></author></analytic><monogr><title level="j">Clin. 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